The cyclization reaction of ortho-ethynylbenzaldehyde derivatives into isoquinoline derivatives.
نویسندگان
چکیده
In order to elucidate the reaction mechanism of the cyclization between an ethynyl group and an imino group at the ortho-position on an aromatic ring to afford isoquinolines, reaction of 2-ethynylbenzaldehydes under various conditions was examined. It is concluded that reaction proceeds via an ionic process and the isoquinoline 4-hydrogen atom derives from the solvent. In addition, it was found that 2-ethynylbenzaldehyde O-methyloximes underwent cyclization in the presence of primary and secondary alcohols to give 3-substituted isoquinolines.
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 48 5 شماره
صفحات -
تاریخ انتشار 2000